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Scientists are unraveling the mechanisms that dictate how the brain and body regulate weight. In four presentations, Dr. Ronald M. Evans and Dr. Jeffrey M. Friedman discuss what the latest advances in genetic and molecular research tell us about why are some people are hefty while others are lean. Understanding the biological systems that control body weight and metabolism, as well as these systems' environmental interactions, could lead scientists to treatments that curb obesity and treat its negative health consequences. DVD includes detailed chapter search by scientific topic, direct access to animations, English subtitles, interviews with the speakers, and special features on the molecular structures of fat, fat metabolism, and measuring obesity. Presented at HHMI's 2004 Holiday Lectures on Science. Two discs, lecture time approx. 240 min.